Plant MedicineGrapefruit
Grapefruit
Citrus × paradisi
Family: Rutaceae
At a glance
Best for: Antioxidant, Vitamin C, Weight management
Common forms: Culinary, Juice
Evidence level: Promising
Cautions: Significant drug interactions with 85+ medications
What it is
Grapefruit is a subtropical citrus hybrid originating in the Caribbean. It is rich in flavonoids, vitamin C, and contains compounds that affect drug metabolism.
Traditional use
A relatively recent fruit (18th century), used culinarily and as a source of vitamin C and antioxidants.
What modern research suggests (Promising)
Well-established drug interaction via furanocoumarins inhibiting CYP3A4. Rich in flavonoids including naringenin with cardiovascular benefits. Some evidence for weight management.
Safety + interactions
Safe as a food. SIGNIFICANT DRUG INTERACTION: grapefruit interacts with over 85 medications including statins, calcium channel blockers, and immunosuppressants. Avoid with many medications.
May interact with: Statins, Calcium channel blockers, Immunosuppressants, Many others—check with pharmacist
Name clarity note
Even half a grapefruit or a glass of juice can cause significant drug interactions that persist for 24+ hours.
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Disclaimer: This content is educational and not medical advice. Always consult a qualified healthcare provider before using any herbs or supplements, especially if you are pregnant, nursing, taking medications, or have a medical condition.