Plant MedicineSkullcap (American)
Skullcap (American)
Scutellaria lateriflora
Family: Lamiaceae
Also known as: Mad dog skullcap
At a glance
Best for: Anxiety, Sleep, Nervous tension
Common forms: Tea, Tincture, Capsule
Evidence level: Traditional-only/Early
Cautions: Adulteration risk—buy from reputable sources; Pregnancy—Avoid
What it is
American skullcap is a native perennial herb of North America. Its aerial parts contain flavonoids (especially baicalin) with calming effects.
Traditional use
Used by various Native American tribes for nervous conditions and as a tonic. Adopted by Eclectic physicians in the 19th century for anxiety and neuralgia.
What modern research suggests (Traditional-only/Early)
Limited but growing clinical evidence for anxiolytic effects. Active compounds bind to GABA receptors. Quality control is a concern—adulteration with germander (hepatotoxic) is documented.
Safety + interactions
Generally safe from reputable sources. Significant adulteration with germander (hepatotoxic) is a concern—buy from trusted sources. Avoid during pregnancy.
May interact with: Sedatives
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Disclaimer: This content is educational and not medical advice. Always consult a qualified healthcare provider before using any herbs or supplements, especially if you are pregnant, nursing, taking medications, or have a medical condition.